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#740135 - 02/23/09 10:44 PM Flagyl and liver problems
DelilahsMom
Unregistered


"Several long-term, oral-dosing studies in the rat have been completed. There were statistically significant increases in the incidence of various neo-plasms (cancer), particularly in mammary and hepatic tumors, among female rats administered metroni-dazole over those noted in the concurrent female control groups."

http://www.rxlist.com/flagyl-drug.htm

"This has been observed in all six reported studies in that species, including one study in which the animals were dosed on an intermittent schedule (administration during every fourth week only). At very high dose levels (approx. 500 mg/kg/day which is approximately 33 times the most frequently recommended human dose for a 50 kg adult based on mg/kg body weight) there was a statistically significant increase in the incidence of malignant liver tumors in males. Also, the published results of one of the mouse studies indicate an increase in the incidence of malignant lymphomas as well as pulmonary neoplasms associated with lifetime feeding of the drug. All these effects are statistically significant.

Several long-term, oral-dosing studies in the rat have been completed. There were statistically significant increases in the incidence of various neoplasms, particularly in mammary and hepatic tumors, among female rats administered metronidazole over those noted in the concurrent female control groups.

Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative.

Although metronidazole has shown mutagenic activity in a number of in vitro assay systems, studies in mammals (in vivo) have failed to demonstrate a potential for genetic damage.

Fertility studies have been performed in mice at doses up to six times the maximum recommended human dose based on mg/m2 and have revealed no evidence of impaired fertility."

http://www.drugs.com/pro/flagyl.html

I wonder how many gliders with liver problems have been on Flagyl?
I know it is prescribed for parasitic infections but I can find NO conclusive evidence that it works for anything other than bacterial infections and amebic dysentery.

Any thoughts?




Edited by LSardou (02/24/09 08:52 AM)
Edit Reason: returned information

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#740145 - 02/23/09 11:01 PM Re: Flagyl and liver problems [Re: ]
LSardou Offline
Glideritis Anonymous

Registered: 03/01/06
Posts: 21060
Loc: Kansas
It would be interesting to look at the HX and the Necropsy reports to compare the past treatments with the use of Flagyl in gliders.

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#740154 - 02/23/09 11:16 PM Re: Flagyl and liver problems [Re: LSardou]
DelilahsMom
Unregistered


I would be more than willing to look into this. I find clinical research to be quite fascinating.

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#740164 - 02/23/09 11:30 PM Re: Flagyl and liver problems [Re: ]
DelilahsMom
Unregistered


...


Edited by DelilahsMom (02/24/09 09:59 AM)

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#740246 - 02/24/09 07:07 AM Re: Flagyl and liver problems [Re: ]
TWilson
Unregistered


I had a glider pass from liver tumors and she had never taken any meds what so ever.

My Dolly was an 8 week old when I got her, she came from a good breeder and never had an illness. She was 15 months old when she passed.

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