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#981007 - 07/25/10 11:10 AM What is a COI and what it really means to you…
Adri Offline
Glider Guardian

Registered: 08/08/08
Posts: 956
Loc: Homestead, FL
In recent months I have seen the community up in arms about COI’s, a lot of stress and confusion has been caused by this little value and here I will make a conscious effort to explain it so that everyone can understand. The formula for the Inbreeding Coefficient was developed by Swell Wright in 1922 and it indicates the probability that any two alleles for any gene are alike by decent, in theory this value can range from 0 to 100%. The inbreeding coefficient is determined by the number and location of a common ancestor within the lineage.

Now you must understand the genetic contribution each ancestor makes:

Parents each parent contributes 50% of the genetic makeup
Grandparents each grandparent contributes 25% of the genetic makeup
Great Grandparents each great grandparent contributes 12.5% of the genetic makeup
Great Great Grandparents each great great grandparent contributes 6.25 % of the genetic makeup

This is where the primary focus in your pairing should be because the likelihood of a trait being inherited beyond this is so unlikely that you probably have better odds of being hit by lightning. With that said, we must also evaluate if there has been any potential genetic issues with the lines you are considering pairing as that will be the most important denominator when assessing the COI.

Many continuously ask why is it ok to breed a glider that is very inbred? And to give it a value we will use a glider with a 25% COI and most importantly why is the COI of the offspring 0% in some cases. Let me explain….because a glider is inbred it does NOT mean it has a genetic defect and IF it does, it does NOT mean it is a dominant mutation. The inbred glider may or may not have health issues of it’s own, if these issues are dominant only one parent must carry the defect for it to manifest in the offspring, with a dominant mutation 50% of the offspring have the POSSIBLITY of inheriting the defect. An example of such a defect would be a polydactyl (having an extra digit). When dealing with a recessive mutation BOTH parents must carry the same defective gene in order for the offspring to inherit it. So you can take two very inbred gliders from completely different lines that don’t share any common ancestors and wind up with a COI of 0% because the offspring will only inherit one copy of the defects each parent may or may not carry, and you would need two copies to be present for a recessive defect to be inherited.

So we come to, what is an acceptable COI? And to that question I don’t have an answer that will apply across the board for every situation. I can tell you what I look for in my breeding COI’s and I can tell you why. All of the pairs I have produce offspring that are below or right at 3% COI within 10 generations. Though I rarely rely on a 10 generation COI because of the ancestral genetic contribution, and I feel a 5 generation COI will more accurately depict the genetic scenario. Now, why do I pair them that way? Because when starting off with a glider that has a very low COI there are more possibilities available when pairing these gliders to produce color. This in it self springs another issue, when you are working with a 0% COI that COI can ONLY go up when pairing said glider back to produce color. This is perfectly OK! You are NOT hurting the lines by this in ANY way. I have seen people hysterical because of a 3 or 4% COI, I have seen them tell others a pairing with a 2.5% should not be done. Why? I can tell you one thing unless you have several secret lines out there that I am not aware of you are going to wind up with COI’s higher than that. If you took the time to research the possibility a young healthy woman with no history of genetic illness has of having a child born with some form of a genetic defect, I assure you the possibilities are much higher than the standards we are trying to set for our gliders. If you stop and actually research our most inbred gliders and their offspring you will find that most of them are living a long healthy life with no signs of illness what so ever that can actually be directly linked with genetics. Sure there have been a few deaths in which a necropsy was not performed or was inconclusive but you will find this with anything. Yet other lines that don’t appear to be severely inbred have had some “questionable coincidences“.

In closing I hope this has helped some of you better understand COI’s and what they really represent to you as an owner and breeder and that this will diminish some of the fear of the unknown .
_________________________
Adri

Mother of 2
Adrian, Sofie
Slave to many glidin' gliders



www.sugarsensation.com

Within the heart of every stray lies the singular desire to be loved.

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#981014 - 07/25/10 11:25 AM Re: What is a COI and what it really means to you… [Re: Adri]
B19 Offline
Glider Lover

Registered: 12/18/09
Posts: 542
Loc: Luverne, Minnesota
GREAT post...thanks that helps a lot!
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Brandi

Loving mother to:
:grey: "Ziggy" & "Teddy"
:rtmo: "Pebbles"
1 chocolate Lab: "Gracie Mae"
1 Min Pin: "Daisy Mae"
2 horses: "Scoots" & "Sisco"


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#981036 - 07/25/10 12:10 PM Re: What is a COI and what it really means to you… [Re: B19]
tjlong Offline
Glider Slave

Registered: 09/25/09
Posts: 1710
Loc: Washington
Thank you for sharing, Adri! thanks
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Tracy
(425) 789-7753
Acres of Sugar

:rtmo: Slave to Several Adorable Gliders :wfb:
~~~~~ :cream: :grey: :leu: :bb: ~~~~~
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#981205 - 07/25/10 06:44 PM Re: What is a COI and what it really means to you… [Re: tjlong]
JamieInWA
Unregistered


Great post Adri!

One question for you...how can we calculate just a 5 gen COI? I use the pet glider database and I don't think I can do it there. Do I need to calculate by hand? If so, how do I do it?

thanks

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#981217 - 07/25/10 07:24 PM Re: What is a COI and what it really means to you… [Re: ]
Adri Offline
Glider Guardian

Registered: 08/08/08
Posts: 956
Loc: Homestead, FL
Jamie in order to have a complete and accurate database I purchased my own program and I have the ability to select the generations I wish to calculate within it. But here is a link that will explain how to calculate the COI manually.
http://pawpeds.com/pawacademy/genetics/genetics/inbreeding.html
In a recent conversation with Priscilla I believe she told me there was a way to do it in her program, I will verify with her and let you know.
_________________________
Adri

Mother of 2
Adrian, Sofie
Slave to many glidin' gliders



www.sugarsensation.com

Within the heart of every stray lies the singular desire to be loved.

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#981224 - 07/25/10 07:37 PM Re: What is a COI and what it really means to you… [Re: Adri]
GliderGuyVA Offline
Glider Lover

Registered: 12/12/08
Posts: 343
Loc: Northern VA.
Well put! I could not have explained it any better smile
_________________________
Slave to:
My Wife
Four - Dogs
Two - Cat's
Four - Ferrets
Eight plus - Gliders

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#981232 - 07/25/10 08:12 PM Re: What is a COI and what it really means to you… [Re: GliderGuyVA]
sketchyglider Offline
Glider Guardian

Registered: 11/21/08
Posts: 928
Loc: Poynette, WI
im glad that someone put this out there! laugh
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Jessee slave to:
Ender :rtmo: & Valentine :leu: and 1 non-fuzzy kid Carleigh

I am SOOOOOO happy to finally be able to have my gliders back home with me! I have missed my babies soo much <3

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#981649 - 07/26/10 03:51 PM Re: What is a COI and what it really means to you… [Re: sketchyglider]
meri Offline
Glider Lover

Registered: 04/09/10
Posts: 504
Loc: nc, usa
agree clap thanks
_________________________
wave Meri & :grey: :leu:

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#981651 - 07/26/10 03:54 PM Re: What is a COI and what it really means to you… [Re: meri]
meri Offline
Glider Lover

Registered: 04/09/10
Posts: 504
Loc: nc, usa
Adri, when you go out more than 5 generations, do you get a coi much different than if you only go 5 generations out?
_________________________
wave Meri & :grey: :leu:

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#981678 - 07/26/10 04:40 PM Re: What is a COI and what it really means to you… [Re: meri]
Adri Offline
Glider Guardian

Registered: 08/08/08
Posts: 956
Loc: Homestead, FL
Meri, you will have varied results. I have seen it change by 0.3% to 1.9% and I'm sure it can vary more or less. It all depends how closely the lines were bred in the earlier generations.
_________________________
Adri

Mother of 2
Adrian, Sofie
Slave to many glidin' gliders



www.sugarsensation.com

Within the heart of every stray lies the singular desire to be loved.

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