So my Co worker got a female glider about 3 weeks or so ago when she was 16 weeks OOP. As of late she's been acting really crabby and biting a lot lately and before she was a real shy girl! I was wondering if gliders entering estrus will have a change in personality?

Although I've never experienced this, I've heard of people refer to it as their 'teenager' stage where they're a little rebellious.

Ok thanks

It is entirely possible. Some people do experience a slight change in personalities with their females. I have never really noticed anything in mine though.